Malignant Leydig Cell Tumor in Elderly Complete Androgen Insensitivity Patient: A Case Report

Sundar Shrestha; Niroj Banepali; Rakesh Sthapit; Dipesh Agrawal

Sundar Shrestha Department of General Surgery, Bir Hospital, NAMS, Kathmandu, Nepal
Niroj Banepali Department of General Surgery, Bir hospital, NAMS, Kathmandu, Nepal
Rakesh Sthapit Department of General Surgery, Bir Hospital, NAMS, Kathmandu, Nepal
Dipesh Agrawal Department of General Surgery, Bir Hospital, NAMS, Kathmandu, Nepal

Abstract

DOI: https://doi.org/10.31729/jnma.4206 There are various cause of Primary amenorrhea in phenotypically females such as, complete androgen insensitivity syndrome, pure gonadal dysgenesis, 17b-hydroxysteroid dehydrogenase deficiency, or mixed gonadal dysgenesis. Primary amenorrhea in a phenotypically female is commonly encountered in Androgen insensitivity syndrome. In patients of AIS with intra-abdominal testis there is high chances of developing testicular tumour, among them Sertoli cell tumour and seminoma being the most common types. Leydig cell tumour in AIS is very rare and malignant leydig cell tumour is even further rarer. There are few case reported in the literatures of malignant leydig cell tumour with complete androgen insensitivity. Here we are reporting a case of 65 years married elderly patient with malignant leydig cell tumour with CAIS.

Keywords: Complete androgen insensitivity syndrome; Leydig cell tumour; Testicular Feminization.