Shrestha, AnneKatie NewtonEmyr BenbowKushwaha, Rajeev2026-10-122026-10-122013https://doi.org/10.31729/jnma.2440https://hdl.handle.net/20.500.14572/8110Abstract Kikuchi-Fujimoto disease, or histiocytic necrotising lymphadenopathy of unknown aetiology, is a rare, benign and self-limiting cause of lymphadenopathy often involving the cervical nodes, and rarely presenting with mesenteric lymphadenopathy. We present a 26-year-old Caucasian male, who presented with right iliac fossa pain and low grade pyrexia, mimicking acute appendicitis. He underwent a laparatomy and an extended right hemi-colectomy for a caecal mass. Histology of the specimen showed lymph nodes with extensive areas of necrosis, with abnormal architecture suggesting Kikuchi-Fujimoto lymphadenopathy. This was further confirmed by immunohistochemistry. In this context maintenance of a high index of suspicion of this condition can avoid major surgical interventions. We describe the management of our case of Kikuchi-Fujimoto’s disease involving the mesenteric nodes and provide an up to date review of the pertinent literature on this subject. Keywords: Abdominal mass; Kikuchi- Fujimoto disease; Mesenteric lymphadenopathy; Necrotising lymphadenitis.en-USAbdominal massKikuchi- Fujimoto diseaseMesenteric lymphadenopathyNecrotising lymphadenitisArticle