Goyal, PSingh, RYadav, ADutta, AKBhattacharjee, J2026-06-042026-06-042010https://hdl.handle.net/20.500.14572/6366P Goyal Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi R Singh Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi A Yadav Department of Biochemistry, Shreemati Sucheta Kripalini Hospital, Lady Hardinge Medical College, New Delhi AK Dutta Department of Paediatrics, Kalawati Saran Children’s Hospital, Lady Hardinge Medical College, New Delhi J Bhattacharjee Department of Paediatrics, Kalawati Saran Children’s Hospital, Lady Hardinge Medical College, New DelhiAbstract: Introduction: Down Syndrome (trisomy 21) provides an interesting natural model to study atherosclerosis, since these individuals appear to be protected from plaque formation. Methodology: We assessed the lipid levels, and superoxide dismutase (SOD) activity in 32 clinically diagnosed children of Down syndrome and 34 children matched for age and sex as controls. Results: SOD activity was found to be significantly higher (p=0.004) in children with Down Syndrome (mean=313.7 IU/ml) than in controls (mean140.2 IU/ ml). Significantly higher levels of serum triglyceride (154.7 mg/dl) and VLDL (33.9 mg/dl) were observed in Down Syndrome as compared to healthy controls (119.6 mg/dl and 23.9 mg/dl respectively; p<0.05 for each). However, the two groups did not show any significant difference in levels of serum HDL-C, LDL-C. Conclusion: The raised antioxidant activity of SOD, because of over expression of genes situated non chromosome 21, probably offers some protection against the development of atherosclerosis despite the occurrence of dyslipidemia.en-USChromosome 21Down SyndromeTrisomy 21Superoxide dismutaseArticle