Amatya, AChoudhary, RZeher, SGurung, GRana, A2026-06-232026-06-232007https://hdl.handle.net/20.500.14572/6745A. Amatya Department of Obstetrics and Gynaecology, TU Teaching Hospital, Maharajgunj R. Choudhary Department of Obstetrics and Gynaecology, TU Teaching Hospital, Maharajgunj S. Zeher Department of Obstetrics and Gynaecology, TU Teaching Hospital, Maharajgunj G. Gurung Department of Obstetrics and Gynaecology, TU Teaching Hospital, Maharajgunj A. Rana Department of Obstetrics and Gynaecology, TU Teaching Hospital, MaharajgunjAbstract Case report: The hemoglobinopathies are a heterogeneous group of single-gene disorders that include the structural hemoglobin variants and the thalassemias. We present a rare case of sickle cell anemia in pregnancy in a young lady who was investigated in the line of jaundice due to hemolytic anemia (suspicion of hemolytic crisis) and associated with Hepatitis E IgM positivity who eventually had a fruitful pregnancy outcome with least maternal and neonatal morbidity. Keywords: Hemoglobinopathies, Hepatitis E IgM positivity in pregnancy, Jaundiceen-USHemoglobinopathiesHepatitis E IgM positivity in pregnancyJaundiceArticle