Shrestha, MoonSubedi, Sudip ChandraShah, SangamAcharya, JenyRegmi, MilanMehta, Neha2025-10-302025-10-302022https://hdl.handle.net/20.500.14572/2917Moon Shrestha Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Sudip Chandra Subedi Kanti Childrens Hospital, Maharajgunj, Kathmandu, Nepal Sangam Shah Maharajgunj Medical Campus, Institute of Medicine, Maharajgunj, Kathmandu, Nepal Jeny Acharya Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Milan Regmi Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal Neha Mehta Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, NepalAbstract Autoimmune hepatitis is a rare form of chronic liver inflammation that begins as acute hepatitis and progresses to chronic liver disease. It presents with varied clinical features from acute hepatitis to chronic liver diseases like chronic viral hepatitis and alcoholic liver disease, making it difficult to diagnose in the absence of a high index of suspicion and adequate laboratory support. Autoimmune hepatitis is divided into two categories autoimmune hepatitis-1 and autoimmune hepatitis-2 based on the antibodies involved. We discuss the case of a 37-year-old woman who developed autoimmune hepatitis-1, with swelling and epigastric pain. These symptoms later progressed to liver cirrhosis leading to the death of the patient. Autoimmune hepatitis is extremely sensitive to immunosuppressive medication, it is necessary to maintain a high suspicion index for the disease because a prompt diagnosis can be an integral step toward a better prognosis of the disease.en-USAutoimmune hepatitisCase reportsChronic hepatitisLiver cirrhosisOther