Pradhan, SusmitaJha, KrishnaKumari, PriyankaShrestha, ShristiJha, Anil Kumar2025-09-252025-09-252022https://hdl.handle.net/20.500.14572/2379Susmita Pradhan Karnali Province hospital, Surkhet Nepal Krishna Jha Department of Dermatology and Venereology, DI Skin Health and Referral Center P Ltd (DISHARC), Maharajgunj, Kathmandu 44600, Nepal; Department of Dermatology, Venereology, and Leprology, Rapti Academy of Health Sciences, Ghorahi, Dang, Nepal Priyanka Kumari Kapan Hospital P Limited, Budhanilkantha-10, Kathmandu, Nepal Shristi Shrestha Department of Dermatology and Venereology, DI Skin Health and Referral Center P Ltd (DISHARC), Maharajgunj, Kathmandu 44600, Nepal; Department of Dermatology, Nepal Medical College and Teaching Hospital, Gokarneshwar, Kathmandu, Nepal Anil Kumar Jha Department of Dermatology and Venereology, DI Skin Health and Referral Center P Ltd (DISHARC), Maharajgunj, Kathmandu 44600, Nepal;Department of Dermatology, Nepal Medical College and Teaching Hospital, Gokarneshwar, Kathmandu, NepalAbstract: We describe a case of a 5-year-old boy who presented with multiple mild itchy and painful blisters predominantly over his trunk and limbs for one year with multiple tense bullae with hypopyon signs resulting in a half-and-half appearance of the blisters. A skin biopsy showed subepidermal separation with predominantly neutrophils and eosinophils in the bulla cavity and mixed infiltrate in the papillary dermis. We would like to report a case of chronic bullous disease of childhood and review its differentials for diagnostic approaches to blistering disease in children.en-USBullous diseaseChildrenHistopathologyImmunohistochemistryArticle