Sah, Dhruba NarayanShrestha, Oshan2025-08-172025-08-172024https://hdl.handle.net/20.500.14572/1693Dhruba Narayan Sah Department of General Surgery, Nobel Medical College Teaching Hospital, Biratnagar, Morang, Nepal Oshan Shrestha Department of Pathology, Nobel Medical College Teaching Hospital, Biratnagar, Morang, NepalAbstract Large cell neuroendocrine carcinoma of the gallbladder is an extremely rare tumour with aggressive behaviour and a bad prognosis. Here, we report a case of a 65-year-old lady suspected of carcinoma of the gallbladder and underwent extended cholecystectomy. The histopathology report revealed neuroendocrine carcinoma of a large cell type of gall bladder infiltrating the liver and three periportal and pericholedochal lymph nodes. She had an uneventful perioperative period and was doing good till 6 months of follow-up. The only potentially curative treatment for large cell neuroendocrine carcinoma of the gallbladder is aggressive surgical resection, owing to its aggressive behaviour and bad prognosis.en-USOther