Rimal, JSumanth, KNOngole, RGeorge, TChatterjee, S2025-07-292025-07-292007https://hdl.handle.net/20.500.14572/912J Rimal Specialist Resident KN Sumanth Associate Professor R Ongole Reader, Department of Oral Medicine and Radiology T George Reader S Chatterjee Post Graduate Student, Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, MangaloreAbstract Pemphigus vulgaris is an autoimmune blistering disease affecting the mucous membrane and skin. Ulcers, vesicles, bulla, erosions are the common manifestations of the disease. It is uncommon to find multiple pustular lesions in the oral cavity. Here, we report the first case of multiple pustules involving the lateral borders of tongue, buccal mucosa, hard palate, soft palate, vestibule and the gingiva of a 53 year old male. Histopathologic and Immunofluoroscence study was suggestive of pemphigus vulgaris. The condition improved with systemic corticosteroid along with adjuvant therapy. Key words: pemphigus vulgaris, multiple pustules, immunofluorescence, corticosteroidsen-USArticle