Sharma, ShriyaSherpa, PasangGiri, Ganesh2025-08-142025-08-142024https://hdl.handle.net/20.500.14572/1540Shriya Sharma Mayo Clinic, Jacksonville, Florida, USA Pasang Sherpa Mayo Clinic, Jacksonville, Florida, USA Ganesh Giri Mayo Clinic, Jacksonville, Florida, USAAbstract In Southeast Asia, the higher prevalence of Intestinal tuberculosis (TB) challenges the diagnosis of Crohn’s disease (CD) due to their overlapping symptoms. This case involves a 25-year-old male misdiagnosed with Intestinal tuberculosis presenting with abdominal pain, weight loss, and bowel ulceration. Recurrence after anti-tubercular therapy led to further investigation paving to right hemicolectomy and histopathological analysis confirming Crohn’s disease. This case highlights the complexity of the diagnosis of Crohn’s disease in tuberculosis-prevalent areas, stressing the clinical importance, advanced diagnostics tools, and multidisciplinary approach for effective intervention.en-USOther