Agrawaal, Krishna KumarKandel, SanjogDevkota, Sudhan2025-09-242025-09-242023https://hdl.handle.net/20.500.14572/2338Krishna Kumar Agrawaal Nephrology Unit, Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Rupandehi, Nepal Sanjog Kandel Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Rupandehi, Nepal Sudhan Devkota Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Rupandehi, NepalAbstract Introduction: Chronic kidney disease is a major cause of mortality with a prevalence of 6%. Over the past half-century, hemodialysis has been the most preferred modality of treatment for sustaining the life of patients with end-stage kidney disease. Despite hemodialysis being freely available, achieving adequacy in hemodialysis is a challenging task. Inadequate dialysis is responsible for the high mortality. This study aimed to find out the mean value of the urea reduction ratio among patients undergoing hemodialysis at a tertiary care centre. Methods: This was a descriptive cross-sectional study conducted from 15 January 2023 to 15 April 2023. Ethical approval was taken from Institutional Review Committee (Reference number: UCMS/IRC/044/23). Patients aged >18 years, undergoing maintenance hemodialysis and giving informed and written consent were included in the study. Urea reduction rate and single-pool Kt/V were estimated. Convenience sampling method was used. Results: Among 100 patients, the mean urea reduction ratio among the study population was 25.24±15.59%. Males represented 62 (62%) of the study population. The mean age was 47.9±14.74 years. Hypertension and Diabetes mellitus was found to be the leading cause of end-stage kidney disease with 61 (61%) and 27 (27%) respectively. The mean value of spKT/V was 0.73±0.162. Conclusions: The mean urea reduction ratio was found to be lower than the other studies done in similar settings.en-USChronic kidney diseaseDialysisHemodialysisArticle