Shrestha, RohitTamrakar, SudichhyaKoju, PrameshMaharjan, SagarMalla, SubhechhyaShrestha, Sony Shakya2024-03-242024-03-242022ShresthaR., TamrakarS., KojuP., MaharjanS., MallaS., & Shakya ShresthaS. (2023). Investigating the Efficacy and Safety of Diacerein in the Management of Knee Osteoarthritis with reference to its conventional management. Journal of Nepal Health Research Council, 20(4), 942-946. https://doi.org/10.33314/jnhrc.v20i4.4323Print ISSN: 1727-5482; Online ISSN: 1999-6217https://hdl.handle.net/20.500.14572/44Original ArticleAbstract Background: Designated as a “priority disease” by World Health Organization, Osteoarthritis is the most common chronic rheumatic disease. Providing a proper treatment for Osteoarthritis is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disease modifying drug used in Osteoarthritis having a risk-benefit ratio far better than conventionally used drugs. However, the evidence of efficacy and safety of use of Diacerein in Osteoarthritis is yet to be explored. Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis. Methods: This is an analytical cohort study comparing Diacerein with Non-steroidal anti-inflammatory drugs for two months in the management of knee OA. Efficacy was assessed by scores of Lysholm Knee Scoring Scale, Knee injury and Osteoarthritis Outcome Score – Physical Function Short form and Western Ontario and McMaster Universities Osteoarthritis Index. Results: After two months of treatment, the post- treatment scores were significantly superior to the baseline scores in both the treatment groups (p<0.001). There were no significant differences among the post-treatment scores in two different treatment groups (p>0.05). Discoloration of urine and gastritis were the frequently reported adverse effects in Diacerein treatment group and Non-steroidal anti-inflammatory drugs treatment group respectively. Conclusions: Our findings have shown Diacerein is as effective as Non-steroidal anti-inflammatory drugs in treating knee OA patients. Diacerein was generally well tolerated, with a good safety profile. These findings indicate the need for further studies with experimental study design in larger scale. Keywords: Diacerein; Efficacy; Knee Osteoarthritis; NSAIDs; SafetyenDiacereinEfficacyKnee OsteoarthritisNSAIDsSafetyJournal Article