Khanal, SumanSingh, Yogendra PShrivastav, Shreya2026-04-052026-04-052019https://hdl.handle.net/20.500.14572/5667Suman Khanal1, Yogendra P Singh2, Shreya Shrivastav3 1Department of Surgical Oncology, BP Koirala Memorial Cancer Hospital 2Department of GI and General Surgery, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu 3Department of Pathology, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Maharajgunj, KathmanduABSTRACT Pregnancy-associated breast cancer is less common and often presents in advanced stage. Management is similar to non-pregnant cases with trimester-specific considerations. In this case report, we present a case of worrisome mother with locally advanced multifocal pregnancy-associated breast cancer who was so much concerned about effects of neoadjuvant chemotherapy on fetus leading to its delayed initiation, and show why targeted therapy is still not within reach in a developing economy like Nepal. Short term data of chemotherapy though reveal relative safety, long term data are lacking. This may be a hindrance in counselling, when patients are more anxious and worrisome. Keywords: Breast cancer, chemotherapy, HER2-neu, pregnancyen-USBreast cancerchemotherapyHER2-neupregnancyArticle