Oli, ParasAdhikari, HariharThapa, Deeptara Pathak2025-12-072025-12-072022https://hdl.handle.net/20.500.14572/3438Paras Oli Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal Harihar Adhikari Department of Dermatology, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal Deeptara Pathak Thapa Department of Dermatology, Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal https://orcid.org/0000-0002-1602-415XAbstract Plasma cell vulvitis is a rare inflammatory disorder of the vulva with an unknown aetiology, characterised by mucosal inflammation. It commonly manifests as pain, itching, dyspareunia, and dysuria and clinically presents as erythematous plaque and macules on the vulva. This condition is refractory to available treatment modalities in the literature. We present a case of a 70-year-old female with histopathologically proven plasma cell vulvitis treated by platelet-rich plasma therapy after multiple failed treatment attempts with topical steroids and immunomodulators. The patient improved both symptomatically and clinically on follow-up with platelet-rich plasma therapy. Platelet-rich plasma which is a new novel treatment can be a therapeutic option for recalcitrant cases of plasma cell vulvitis.en-USCase reportImmunosuppressantPlatelet-rich plasmaVulvitisOther