Karki, PrakritiPahari, SagarNeupane, NayanPoudel, KushalAsharaf, Nehal2025-07-312025-07-312024https://hdl.handle.net/20.500.14572/1099Prakriti Karki Tairunnessa Memorial Medical College and Hospital,Gazipur,Bangladesh Sagar Pahari Tribhuvan University Teaching Hospital,Maharajgunj,Kathmandu,Nepal Nayan Neupane Nepal Medical College,Jorpati,Kathmandu,Nepal Kushal Poudel Nepalgunj Medical College,Nepalgunj,Banke,Nepal Nehal Asharaf Bir Hospital, Mahaboudha, Kathmandu, NepalAbstract Neuromyelitis optica spectrum disorder also known as Devic's disease is an autoimmune condition where the body produces antibodies against Aquaporin-4 in the astrocytes. This affects the brain and spinal cord leading to numerous manifestations like paralysis, transverse myelitis, and optic neuritis. MRI and aquaporin-4 antibody (AQP4-IgG) are crucial for its diagnosis. Treatment of the acute stage involves plasma exchange and intravenous steroids. Steroids and immune modulators can do long-term management. This case highlights a 40-year-old woman who manifested a wide range of neurological symptoms, including paralysis and eyesight loss. She had blood testing, radiology, and a clinical evaluation to diagnose her condition. Neuromyelitis optica spectrum disorder was diagnosed in light of the investigations. This instance emphasizes the need for careful examination and consideration of any paralysis. To prevent patients from experiencing psychological, financial, or physical challenges, treating physicians should be vigilant for any findings related to conditions like neuromyelitis optica spectrum disorder.en-USOther