Yagi, NatsukiSugitate, RyoShimizu, MarikoOgata, Tomomi2025-10-302025-10-302023https://hdl.handle.net/20.500.14572/2941Natsuki Yagi Department of Paediatrics, Japanese Red Cross Maebashi Hospital, 389-1 Asakuramachi, Maebashi, Gunma 371-0811, Japan Ryo Sugitate Department of Paediatrics, Japanese Red Cross Maebashi Hospital, 389-1 Asakuramachi, Maebashi, Gunma 371-0811, Japan Mariko Shimizu Department of Paediatrics, Japanese Red Cross Maebashi Hospital, 389-1 Asakuramachi, Maebashi, Gunma 371-0811, Japan Tomomi Ogata Department of Paediatrics, Gunma University Graduate School of Medicine, Chome - 39-22 Showamachi, Maebashi, Gunma 371-0034, JapanAbstract: There have been few reports of mild encephalopathy with reversible splenic lesions (MERS) associated with COVID-19 in infants. Here, we present a case of MERS in a 23-month-old infant with COVID-19 in Japan during the Omicron variant epidemic. The increase in COVID-19 acute encephalopathy in infants, including those with MERS, should be considered in the future due to the prevalence of the Omicron variant strain. Meanwhile, whether the cause is COVID-19, acute encephalopathy with a lesion localized in the splenium of the corpus callosum can be treated with temporary anticonvulsant therapy, as is generally the case with MERS.en-USArticle