Khadka, NishaShakya, SubijKhatiwada, DikshyaBudhathoki, PravashBhattarai, Tulsi Ram2026-02-112026-02-112022https://hdl.handle.net/20.500.14572/4656Nisha Khadka Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal https://orcid.org/0000-0003-0580-377X Subij Shakya Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Dikshya Khatiwada Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal https://orcid.org/0000-0003-4843-1048 Pravash Budhathoki Department of Internal Medicine, Bronx Lebanon Hospital, USA Tulsi Ram Bhattarai Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, NepalAbstract: Stevens-Johnson syndrome and toxic epidermal necrolysis represent a spectrum of severe mucocutaneous reactions, while Acute Cutaneous Lupus Erythematosus is a variant of Systemic Lupus Erythematosus. Both are rare conditions, with significant morbidity and mortality; often indistinguishable clinically and pose a diagnostic dilemma for the clinician. We hereby present a unique case of a 17 years old female who presented with widespread vesiculobullous lesions with peeling, desquamation, and crusting of the skin surface, non-scarring alopecia, oral and nasal ulcers, as well as two episodes of generalized tonic-clonic seizures. The patient had a history of intake of itraconazole tablets for a week, 25 days before the disease manifestation.en-UScase reportcutaneous lupus erythematosusrheumatologystevens-johnson syndrome.Article