Swaroop, ShikhaMittal, MedhaNair, SmitaSaini, ReetikaBagla, Jyoti2025-10-312025-10-312022https://hdl.handle.net/20.500.14572/2975Shikha Swaroop Assistant Professor, Manipal Tata Medical College, Jamshedpur, India Medha Mittal Associate Professor, Department of Paediatrics, Chacha Nehru Bal Chikitsalaya, Delhi, India Smita Nair Assistant Professor, SMS and R, Sharda Hospital, Delhi, India Reetika Saini Research Officer, Central Ayurveda Research Institute, Punjabi Bagh, New Delhi, India Jyoti Bagla Professor and HOD, Department of Paediatrics, ESI Postgraduate Institute of Medical Education and Research, Basaidarapur, Delhi, IndiaAbstract: Introduction: Various research works have reported elevated serum homocysteine levels with the use of antiepileptic drugs. This may lead to an increased risk of atherosclerosis, a higher seizure frequency and may also cause cognitive decline. Methods: Twenty five children (Two to 12 years) on valproate monotherapy for more than one year and the same number of age and sex-matched healthy controls were enrolled. Venous blood samples were analyzed for serum homocysteine, vitamin B12 and folic acid levels. All biochemical parameters were compared between the groups. Results: The antiepileptic drug users had significantly lower serum homocysteine levels and higher B12 levels as compared to the controls. But serum folate levels were similar between the groups. No correlation of serum homocysteine levels was observed with either serum folate, B12 or valproate. Conclusions: The use of valproate monotherapy for epilepsy in the Indian paediatric population does not increase the risk of hyperhomocysteinemia.en-USFolic acidHomocysteineVitamin B12sodium valproateArticle