Shukla, SaumyaAwasthi, Namrata PunitHusain, NuzhatNidhi Anand2026-10-062026-10-062014https://doi.org/10.31729/jnma.2804https://hdl.handle.net/20.500.14572/7971Abstract We report the cytological findings of a sacro-coccygeal chordoma in a 53 year male diagnosed preoperatively by guided fine needle aspiration cytology. The smears shows characteristic Physalliphorous cells in a metachromatic background of myxoid material entrapping cords of cuboidal cells. Differential diagnosis in cytology include conventional and myxoid chondrosarcoma, myxoid liposarcoma, myxoid malignant fibrous histiocytoma, metastatic mucinous carcinoma and myxo-papillary ependymoma. The distinguishing features between these neoplasms are discussed. Preoperative diagnosis of chordoma permits optimum planned surgery. Keywords: Chordoma; Myxoid; Sacral.en-USChordomaMyxoidSacralArticle