Shrestha, Deepak SundarLove, Richard R.Paudel, Bishnu Dutta2026-02-112026-02-112022https://hdl.handle.net/20.500.14572/4659Deepak Sundar Shrestha Richa Bajimaya Memorial Foundation, Kathmandu, Nepal https://orcid.org/0000-0002-7051-4088 Richard R. Love Department of Computer Science, Marquette University, Milwaukee, Wisconsin, U.S.A. https://orcid.org/0000-0002-0775-2753 Bishnu Dutta Paudel Bhaktapur Cancer Hospital, Bhaktapur, NepalAbstract: In Nepal, the commonest major malignancies and causes of cancer death are lung, cervix, stomach, breast, head and neck (lip, mouth, pharynx, larynx), gallbladder, ovary and liver. There are seven cancer-causative exposures which should be the focus of attention such as; tobacco smoking in 29% of men, and 6% of women, solid fuel burning in 69% of homes (multiple cancers), betel-nut chewing in 40 % of men and 3% of women (head and neck cancers), alcohol abuse (liver and other cancers), Human Papilloma Virus (cervical cancer), Helicobacter pylori (stomach cancer) and Hepatitis B virus (liver cancer). To better address these reducible exposures, we suggest greater targeted strategies in three areas: Public health messaging for tobacco, solid-fuel burning, betel-nut, and alcohol; national policies for Hepatitis B virus vaccination; and analytic epidemiological and interventional research for Human Papilloma Virus and helicobacter.en-USalcohol drinkingbetel nuthelicobacter pylorihuman papilloma virustobacco smoking.Article