Dahal, AgnimshworDhungel, PrakashThapa, AsthaGyawali, JeevanShah, AminKhadgi, PujanChauhan, BhimKarki, Prashanna DipShahi, Nistha2025-08-012025-08-012024https://hdl.handle.net/20.500.14572/1124Agnimshwor Dahal Nepal Intensive Care Research Foundation, Kathmandu, 44600, Nepal Prakash Dhungel Patan Academy of Health Sciences – School of Medicine (PAHS-SOM), Lalitpur, 44700, Nepal Astha Thapa Shahid Dharmabhakta Transplant Center, Bhaktpur, Nepal Jeevan Gyawali Patan Academy of Health Sciences – School of Medicine (PAHS-SOM), Lalitpur, 44700, Nepal Amin Shah Patan Academy of Health Sciences – School of Medicine (PAHS-SOM), Lalitpur, 44700, Nepal Pujan Khadgi Nepal Medical College, Kathmandu, 44600, Nepal Bhim Chauhan Patan Academy of Health Sciences – School of Medicine (PAHS-SOM), Lalitpur, 44700, Nepal Prashanna Dip Karki National Trauma Center, Kathmandu, 44600, Nepal Nistha Shahi Karnali Province Hospital, Surkhet, NepalAbstract Erythema Multiforme Major (EMM) is a rare hypersensitivity reaction that primarily affects the skin and mucosa, typically self-limiting. This case discusses a patient who developed severe EMM lesions after consuming nimesulide, a non-steroidal anti-inflammatory drug (NSAID), for abdominal discomfort. Patient was admitted to the hospital, the drug was discontinued, and supportive measures such as pain management and fluid replacement were initiated. This case, being the first to identify nimesulide as a possible trigger for EMM, aims to contribute to the growing body of knowledge on this topic. It emphasizes the need for vigilance and swift intervention for unusual drug reactions.en-USOther