Dhakal, NeelamPoudyal, AnilGyanwali, Pradip2026-02-262026-02-262021https://hdl.handle.net/20.500.14572/4965Neelam Dhakal Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal Anil Poudyal Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal Pradip Gyanwali Nepal Health Research Council, Ramshah Path, Kathmandu, NepalAbstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is alarming worldwide incurring tremendous loss of life and possession. Individuals are facing a terrible pandemic condition in the absence of appropriate medicines and vaccines to combat SARS-CoV-2 infection. This review aimed to provide details on potential treatment steps that can be taken in the current pandemic-fighting situation in Nepal. A massive review was performed including 60 articles from the relevant field. Preliminary results on the efficacy of some existing anti-viral agents were found, however, promising data on effective treatment regimen for COVID 19 are yet to be obtained. This review examines various drugs and their mechanism of actions which are currently used in clinical trials or may be used to treat COVID-19 in the near future.en-USCOVID-19pharmacological treatmentvaccinesArticle