Jha, ASharma, SKhadga, PKPathak, RPoudyal, SHamal, R2026-04-212026-04-212017https://hdl.handle.net/20.500.14572/5833A Jha Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of Medicine S Sharma Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of Medicine PK Khadga Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of Medicine R Pathak Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of Medicine S Poudyal Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of Medicine R Hamal Department of Gastroenterology, Tribhuvan University Teaching Hospital, Institute of MedicineAbstract Introduction: Bleeding is a common presentation in the Department of Gastroenterology, Institute of Medicine, Tribhuvan University Teaching Hospital. Of the varied causes of upper gastrointestinal bleed, bleeding gastric varices pose a major challenge to the endoscopist and the treating physician. Endoscopic injection of N-butyl-2-cyanoacrylate is the standard of care for treating gastric varices at present. Methods: We retrospectively evaluated the efficacy and safety of cyanoacrylate in patients presenting with gastric variceal bleed. Between May 2016 to April 2017, 25 patients (14-M, 11-F) who presented to Institute of Medicine, Tribhuvan University Teaching Hospital with gastric variceal bleeding underwent endoscopic treatment with N-butyl-2-cyanoacrylate. Results: Eleven patients had cirrhosis secondary to alcohol, 9 had non-cirrhotic portal hypertension, cirrhosis due to hepatitis B-1, hepatitis C-1, NASH-1, and cryptogenic- 2. Child-Pugh score at presentation for patients was Child A-52%, Child B-36% and Child C-12. Successful hemostasis. rebleeding rate and complications were reviewed. Immediate hemostasis was observed in 100 of the cases and carly rebleeding rate of 8% was seen in 2 patients. Complications included post procedure pain 16%, fever 16% and pulmonary embolism 4%. Conclusion: N-butyl-2-cyanoacrylate is an effective, lifesaving modality for immediate hemostasis of gastric variceal bleeding with an acceptable rebleeding rate. Keywords: N-butyl-2-cyanoacrylate, endoscopic injection, gastric variceal bleeden-USN-butyl-2-cyanoacrylateendoscopic injectiongastric variceal bleedArticle