Kamar, Sher BahadurBhatta, Uttam KumarSingh, RatnaTimilsana, Manju Paudel2025-08-062025-08-062022https://hdl.handle.net/20.500.14572/1319Sher Bahadur Kamar Department of Internal Medicine, Seti Provincial Hospital Uttam Kumar Bhatta Department of Internal Medicine, Seti Provincial Hospital Ratna Singh Intensive Care Unit, Seti Provincial Hospital Manju Paudel Timilsana Medical ward Seti Provincial HospitalAbstract A 16-year-old boy who classically featured Guillain Barre Syndrome (GBS) after Corona Virus Disease-19 vaccination was timely treated successfully in limited resource setting in far western province. After Moderna (mRNA COVID 19 Vaccine) vaccination, he rapidly developed ascending paralysis of limbs without autonomic and sensory or cranial nerve involvement. He has been treated with Intravenous Immuno-Globulin (IVIG). Over six-weeks long observation and supportive care and he was discharged with full recovery. Many GBS cases after vaccination have been reported but yet to know the association of vaccine. It is very important to address the complication for successful vaccination programme. Keywords: Complication; COVID-19; guillain barre syndrome; vaccineen-USArticle