Rijal, JayaRijal, SatyaUpadhyay, Radhika2025-07-282025-07-282025https://hdl.handle.net/20.500.14572/828Jaya Rijal Texas Woman’s University College of Nursing, Satya Rijal Michigan State University College of Human Medicine, Department of Internal Medicine Radhika Upadhyay Nepalgunj Nursing Campus, Institute of Medicine, Tribhuvan UniversityAbstract Postpartum depression remains a critical concern in Nepal, influenced by various socio-cultural and healthcare-related factors. Therefore, this integrative review aimed to analyze and synthesize its key determinants within the Nepalese context. Fourteen articles met the eligibility criteria after systematically searching five electronic databases. The review underscores that increased age, low socioeconomic status, limited educational attainment, unintended pregnancies, inadequate support, and maternal health issues are the prominent risks. Cultural inclinations, such as a preference for male children and lack of adequate antenatal care, contribute to the severity of the condition. The findings stress the need for culturally sensitive strategies, early screening efforts, and the assimilation of mental health care and maternal services. It advocates for focused interventions and future longitudinal studies, and the insights are valuable for healthcare professionals, policymakers, and future investigations to improve maternal health outcomes in Nepal.en-USArticle