Maharjan, NarayaniThapa, NireshTu, Jiancheng2026-08-072026-08-072020https://hdl.handle.net/20.500.14572/7167Narayani Maharjan Department of Clinical Laboratory Medicine and Centerfor Gene Diagnosis, Zhongnan Hospital of Wuhan University http://orcid.org/0000-0002-8930-7409 Niresh Thapa Karnali Academy of Health Sciences, Jumla, Nepal Jiancheng Tu Department of Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, P. R. ChinaAbstract Lung cancer is the severe leading cause of cancer-related mortality worldwide. Early detection of lung cancer can significantly increase their survival rate. However, conventional lung cancer screening methods such as sputum cytology, chest X-rays, low-dose computed tomography, positron emission tomography, and magnetic resonance imaging, are radiational, and also expensive methods. Similarly, lung tumor tissue as invasive and difficult to obtain and potentially risky procedures, there is the immediate need of non-invasive, novel sensitive and reliable blood-based tumor markers which now has become an important area on research. This review will mainly focus on recently identified circulating biomarkers: circulating tumor cells, circulating tumor deoxyribonucleic acid, tumor-derived exosomes, circulating ribonucleic acid and micro ribonucleic acid, and tumoreducated platelets which may enable earlier diagnosis of lung cancer and their application in clinical practices. Keywords: biomarkers, blood, early diagnosis, lung neoplasms, microRNAsen-USbiomarkersbloodearly diagnosislung neoplasmsmicroRNAsArticle