Amatya, PujaRajbhandari, RateenaTuladhar, SucharitaBasnet, SangitaOjha, Anil RajShrestha, Shrijana2025-10-142025-10-142024https://hdl.handle.net/20.500.14572/2685Puja Amatya Associate Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal. https://orcid.org/0000-0003-2264-9938 Rateena Rajbhandari Assistant Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal. Sucharita Tuladhar Assistant Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal. Sangita Basnet Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal. Anil Raj Ojha Associate Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal. Shrijana Shrestha Professor, Department of Paediatrics, Patan Academy of Health Sciences (PAHS), Patan Hospital, Lagankhel Rd, 44700, Lalitpur, Nepal.Abstract: Introduction: Multisystem inflammatory syndrome in children (MIS-C) manifests a few weeks after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is characterized by fever and multi-organ dysfunction. This disease has been increasingly reported from various countries since the outbreak of coronavirus in 2019. This study was done to determine the clinical characteristics and outcome of children with multisystem inflammatory syndrome in our settings. Methods: This was a retrospective study in children aged 1 month to 14 years fulfilling the World Health Organization case definition of MIS-C conducted between January 2020 and March 2022 in a tertiary care center, Nepal. The clinical characteristics, treatment and outcome parameters of these patients were reviewed and analyzed. Results: A total of 36 patients with MIS-C was reviewed, 20 (55.5%) were male with median age of 6 years (IQR 1.6-10). All children with MIS-C had fever while gastrointestinal symptoms were present in 24 (66.6%), cough in 15 (41.7%) and rash in 13 (36%). Twelve patients (33.3%) had cardiac symptoms of which 3 (8%) patients had dilated coronary arteries. Other presentations were Kawasaki disease like features (8), toxic shock syndrome (5), meningoencephalitis (3), subconjunctival hemorrhage (1), and pulmonary edema (1). Intravenous immunoglobulin was given in 18 (50%) patients, steroid in 23 (64%) and aspirin in 30 (83.3%) patients. All patients survived. Conclusion: The most common symptoms of multisystem inflammatory syndrome in children were fever, gastrointestinal symptoms, cough and rash. The overall outcome of patients even with severe disease was good.en-USMultisystem Inflammatory Syndrome in Children (MIS‐C)COVID-19severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Article