Shrestha, BL2026-01-092026-01-092024https://hdl.handle.net/20.500.14572/4178BL Shrestha Department of ENT-HNS Dhulikhel Hospital, Kathmandu University Hospital Kathmandu University School of Medical Sciences Dhulikhel, Kavre, NepalABSTRACT The introduction of biologics into otorhinolaryngology has marked a significant shift in the management of complex and chronic ENT (Ear, Nose and Throat) conditions. This review delves into the mechanisms, clinical applications, and evidence supporting the use of biologics in treating disorders such as chronic rhinosinusitis, allergic rhinitis, head and neck cancer, and autoimmune inner ear disease. By examining current research and clinical trials, this article provides an in-depth analysis of the transformative impact of biologics and discusses future directions in this rapidly advancing field. KEY WORDS Biologics, chronic rhinosinusitis, Ear, Nose and Throaten-USBiologicschronic rhinosinusitisEarNose and ThroatArticle