Keyal, Niraj KumarJha, SudhakarParween, ShahnajHaque, Ishfa BanuAnsari, TauqueerAnsari, Istiyaque2025-07-132025-07-132025https://hdl.handle.net/20.500.14572/122Niraj Kumar Keyal Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal https://orcid.org/0000-0001-8587-1718 Sudhakar Jha Department of Internal Medicine, National Medical College, Birgunj, Nepal Shahnaj Parween Department of Anaesthesiology, National Medical College, Birgunj, Nepal Ishfa Banu Haque Department of Oral and Maxillofacial Surgery, National Academy of Medical Sciences, Bir Hospital Tauqueer Ansari Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal Istiyaque Ansari Department of General Practice and Emergency Medicine-Critical Care Medicine Unit, National Medical College, Birgunj, Nepal.Background: Acute physiology and chronic health evaluation –II (APACHE-II) and Sequential organ failure assessment (SOFA) is used to predict overall mortality and sepsis outcome in the intensive care unit (ICU) respectively. There are limited studies that have shown that both score can be used to predict mortality in surgical and medical patients admitted in the intensive care unit. Methods: It was a prospective, observational study in a level three intensive care unit of National Medical College, Birgunj. This study was conducted in 542 patients admitted in the mixed intensive care unit of medical; college. Demographic data was gathered from each patient in the preformed sheet at the time of presentation to the intensive care unit. Outcome of patients was recorded in terms of mortality, discharge toward and leave against medical advice. The descriptive data are presented as the number and percentage for categorical data and mean ± standard deviation for continuous data according to their distribution Results: Five hundred forty two patients were included in this study. 340(62.7%) were males and 202(37.3%) were females. 440(81%) patients survived and went home, 65(12%) expired, 26(5%) left the hospital against medical advice (LAMA) and 11(2%) gave do not resuscitate orders (DNR). The discrimination power was similar for APACHE II and SOFA scores (AUC=0.732 versus 0.771, respectively, p>0.05). APACHE II score>8.5 and SOFA >3.5 was cut off to predict mortality. Conclusions: SOFA and APACHE II has similar discriminating power to predict mortality in all group of patients in a mixed intensive care unit. Keywords: APACHE II; intensive care units; SOFA.en-USA Prospective Observational Study on Use of Acute Physiology and Chronic Health Evaluation-II and Sequential Organ Failure Assessment Score to Predict OutcomeArticle