Basnet ATamang, BPokhrel, NKhadka, SShrestha, MRGhimire, SPrajapati, RThapa SDuwal Shrestha, SKChand, ABAmatya, IRai, SK2025-12-262025-12-262022https://hdl.handle.net/20.500.14572/3875Basnet A,1,2 Tamang B,2 Pokhrel N,3 Khadka S,4,5 Shrestha MR,2 Ghimire S,2 Prajapati R,2 Thapa S,2 Duwal Shrestha SK,6 Chand AB,7 Amatya I,3 Rai SK8 1Department of Medical Microbiology Shi-Gan International College of Science and Technology, Tribhuvan University Shankha marg, Kathmandu, Nepal 2Department of Clinical Laboratory, Nepal Armed Police Force Hospital, Balambu, Kathmandu, Nepal 3Research Section, Nepal Health Research Council Kathmandu, Ramshah path, Kathmandu, Nepal 4Department of Immunology, Mayo Clinic Rochester, Minnesota, United States 5Department of Microbiology and Immunology Stanford University, Palo Alto, California United States 6Department of Orthopedic Nepal Armed Police Force Hospital Balambu, Kathmandu, Nepal 7Department of Clinical Laboratory KIST Medical College and Teaching Hospital Gwarko, Lalitpur, Nepal 8Research Division Nepal Medical College and Teaching Hospital Gokarneswor-08, Kathmandu, NepalABSTRACT Background Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) variants, which have emerged due to several mutations in spike protein, have a potential to escape immune protection provided by the first-generation vaccines, thereby resulting in breakthrough infections. Objective To identify the socio-demographic factors, clinical features, and outcomes in both vaccinated and unvaccinated hospitalized patients infected with SARS-CoV-2. Method Socio-demographic details, clinical features, and the outcomes among fully vaccinated (double for Covishield/AstraZeneca and BBIBP-CorV and single for Janssen), partially vaccinated, and unvaccinated hospitalized patients with coronavirus disease of 2019 (COVID-19) were collected and analyzed using SPSS version 17. Result Among the hospitalized COVID-19 patients (n=299), 175 (58.5%) patients received a single-dose, 82 (27.4%) double-dose, and 124 (41.5%) did not receive any dose of the COVID-19 vaccines. The risk of SARS-CoV-2 infection when compared between vaccinated and unvaccinated patients was found to be associated among professional degree holders (23.4% versus 9.7%) (p<0.05), professional workers (43.4% vs. 25.0%) (p<0.05), hospitalization to general ward (76.6% vs. 72.6%) (p<0.05), and presence of multiple symptoms (≥3) (86.8% vs. 75.0%) (p>0.05) and comorbidities (≥2) (15.5% vs. 13.7%) (p>0.05). Despite such approximate incidences, the risk of in-hospital mortality among the vaccinated patients was reduced (0.6% vs. 3.2%) (p>0.05), when compared to the unvaccinated patients. The risk of in-hospital mortality was associated with the older age and the presence of multiple comorbidities including bronchial asthma, diabetes, and hypertension. Conclusion Full or partial vaccination against the SARS-CoV-2 variants of concerns might be effective in preventing in-hospital mortality among COVID-19 patients. KEY WORDS COVID-19, Clinical features, SARS-CoV-2, Socio-demographic factors, Vaccine, Variantsen-USCOVID-19Clinical featuresSARS-CoV-2Socio-demographic factorsVaccineVariantsArticle