Marla, VHegde, VShrestha, A2025-10-082025-10-082015https://hdl.handle.net/20.500.14572/2517Marla V,1 Hegde V,2 Shrestha A1 1Department of Oral Histology and Pathology College of Dental Surgery BP Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal. 2Department of Oral Pathology and Microbiology SDM College of Dental Sciences, Sattur, Dharwad, KarnatakaABSTRACT Angiogenesis is an important aspect of a variety of physiological and pathological processes; and depends on the alteration of the balance between pro-angiogenic and anti-angiogenic factors. The role of angiogenesis in the progression and metastasis of neoplasm is a well established phenomenon. With regards to oral squamous cell carcinoma, it is a field of ongoing research and requires validation for it being used as a mode of anti-cancer therapy. This review focuses on the concept of angiogenesis, the factors associated with it, the relationship of angiogenesis with oral epithelial dysplasia and oral squamous cell carcinoma; the methods of studying angiogenesis and anti angiogenic therapy. KEY WORDS Angiogenesis, neoplasm, oral squamous cell carcinoma.en-USAngiogenesisNeoplasmOral squamous cell carcinomaArticle