Pandey, SShrestha, NSThapa, M2025-07-282025-07-282007https://hdl.handle.net/20.500.14572/835Pandey S1, Shrestha NS2, Thapa M 3 1Medical Officer,2,3 Lecturer, Department of Obstetrics & Gynaecology, Kathmandu Medical College, Sinamangal, Kathmandu.Locally invasive non-metastatic persistent gestational trophoblastic tumours (PGTT) following a non-molar pregnancy occur very rarely. Non-metastatic tumours usually falls in low risk group in WHO scoring system based on prognostic factors. We report a case of high risk non-metastatic PGTT which followed a spontaneous first trimester abortion. Complete remission of the tumour was achieved by chemotherapy EMA-CO regimen. Key words: Persistent gestational trophoblastic tumour, Abortion, Chemotherapyen-USArticle