Shrestha, Lok BahadurSyangtan, GopiramBasnet, AjayaAcharya, Krishna PrasadChand, Arun BahadurPokhrel, Khilasa2026-03-102026-03-102021https://hdl.handle.net/20.500.14572/5010Lok Bahadur Shrestha School of Medical Sciences and The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia https://orcid.org/0000-0002-0054-0715 Gopiram Syangtan Tribhuvan University, Shi-Gan International College of Science and Technology, Kathmandu, Nepal Ajaya Basnet Tribhuvan University, Shi-Gan International College of Science and Technology, Kathmandu, Nepal Krishna Prasad Acharya Animal Quarantine Office, Budhanilkantha, Kathmandu, Nepal Arun Bahadur Chand Department of Clinical Laboratory, Kist Medical College & Teaching Hospital, Kathmandu, Nepal Khilasa Pokhrel Department of Microbiology, Kathmandu Medical College, Sinamangal, Kathmandu, NepalAbstract: Staphylococcus aureus is both a frequent commensal and a leading cause of endocarditis, bacteremia, osteomyelitis and skin and soft tissue infections and device-related infections. We performed this minireview to summarize the prevalence of Staphylococcus aureus among clinical samples and estimate the proportion of methicillin-resistant Staphylococcus aureus. The prevalence of Staphylococcus aureus among clinical isolates in Nepal is 34.5%. On average, the proportion of multi-drug resistance in Staphylococcus aureus is 57.1%. Methicillin-resistant Staphylococcus aureus accounts for a total of 41.7%. Inducible clindamycin resistance was detected in about 35% of the isolates. A regular antimicrobial resistance surveillance mechanism is necessary to mitigate the development of resistance among organisms and further spread of superbugs like methicillin-resistance Staphylococcus aureus.en-USclindamycinmethicillin-resistant Staphylococcus aureusmulti drug resistanceArticle