Basnet, SangitaShrestha, DhrubaAmatya, PujaSharma, ArunBajracharya, Binod LalShrestha, AnilShrestha, SudeepRajchal, PramilaKafle, RajuShrestha, DevendraPuri, SangeetaBhatta, AnweshPathak, Om KrishnaShrestha, Shrijana2025-12-122025-12-122021https://hdl.handle.net/20.500.14572/3577Sangita Basnet Department of Paediatrics, Southern Illinois University, School of Medicine, Springfield, Illinois, USA and Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal https://orcid.org/0000-0002-0657-8386 Dhruba Shrestha Department of of Paediatrics, Siddhi Memorial Women and Children's Hospital, Bhaktapur, Nepal Puja Amatya Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, Nepal Arun Sharma Department of Paediatrics, Tribhuvan University Teaching Hospital, Kathmandu, Nepal Binod Lal Bajracharya Department of Paediatrics, Past President of NEPAS Anil Shrestha Department of Paediatrics, Kanti Children’s Hospital, Kathmandu, Nepal Sudeep Shrestha Specialty Trainee, Tunbridge Wells Hospital, UK Pramila Rajchal Department of Paediatrics, Scheer Adventist Memorial Hospital, Banepa, Nepal Raju Kafle Department of Paediatrics, Universal College of Medical Sciences, Bhairahwa, Nepal Devendra Shrestha Department of Paediatrics, KIST Hospital, Kathmandu, Nepal Sangeeta Puri Department of Paediatrics, Nepal Medical College, Kathmandu, Nepal Anwesh Bhatta Department of Paediatrics, Kathmandu Medical College, Kathmandu, Nepal Om Krishna Pathak Department of Paediatrics, Bharatpur Hospital, Chitwan, Nepal Shrijana Shrestha Department of Paediatrics, Patan Academy of Health Sciences, Lalitpur, NepalAbstract: Justification: Sepsis is a major cause of morbidity and mortality in Nepal. There is a lack of standardisation in the management of severe sepsis and septic shock. Additionally, international guidelines may not be completely applicable to resource limited countries like Nepal. Objective: Create a collaborative standardised protocol for management of severe sepsis and septic shock for Nepal based on evidence and local resources. Process / Methods: Paediatricians representing various paediatric intensive care units all over Nepal gathered to discuss clinical practice and delivery of care of sepsis and septic shock under the aegis of Nepal Paediatric Society. After three meetings and several iterations a standardised protocol and algorithm was developed by modifying the existing Surviving Sepsis Guidelines to suit local experience and resources. Recommendations: Paediatric sepsis and septic shock definitions and management in the early hours of presentation are outlined in text and flow diagram format to simplify and standardise delivery of care to children in the paediatric intensive care setting. These are guidelines and may need to be modified as necessary depending on the resources availability and lack thereof. It is recommended to analyse data moving forward and revise every few years in the advent of additional data.en-USSepsisseptic shockpediatricsNepalGuidelinesmanagementCritical careArticle