Roy, SoumyaChakrabartty, Subroto2026-02-092026-02-092017https://hdl.handle.net/20.500.14572/4596Soumya Roy Institute Of Child Health, Kolkata Subroto Chakrabartty Institute Of Child Health, KolkataAbstract: A four year old girl with systemic onset juvenile idiopathic arthritis (SOJIA) developed macrophage activation syndrome (MAS) shortly after starting methotrexate. We observed methotrexate is a likely trigger of MAS in SOJIA. Possibly, there are only two case reports suggesting methotrexate triggered MAS. We reviewed the literature for possible mechanisms.en-USMacrophage activation syndromeMethotrexateSystemic Onset Juvenile Idiopathic ArthritisArticle