Bhattarai, SujuPudasaini, JyotiSharma, AshutoshBharati, ManjilDhakal, Narayan2025-08-252025-08-252023https://hdl.handle.net/20.500.14572/2004Suju Bhattarai Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Jyoti Pudasaini Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Ashutosh Sharma Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Manjil Bharati Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Narayan Dhakal Department of Internal Medicine, Shree Birendra Hospital, Chhauni, Kathmandu, NepalAbstract The overlap of systemic sclerosis and inflammatory myositis is a rare disorder which results in immune system activation and production of autoantibodies. We present a case of a 28-year-old female with complaints of generalized weakness, multiple joint pain, facial puffiness, and blackish discolouration of skin over the last 4 months. Blood investigations demonstrated autoantibodies positive for overlap syndrome. She was managed with hydroxychloroquine, mycophenolate mofetil and steroids. This case report highlights the importance of early diagnosis and treatment of this rare entity for better patient outcomes.en-USOther