Ngo, Quang ChiTran, Hung DoMai, Trang ThuyTran, Khanh Cong Nguyen2025-10-132025-10-132025https://hdl.handle.net/20.500.14572/2634Quang Chi Ngo Department of Paediatrics, Can Tho University of Medicine and Pharmacy, Vietnam Hung Do Tran Department of Paediatrics, Can Tho University of Medicine and Pharmacy, Vietnam Trang Thuy Mai Department of Paediatrics, Can Tho University of Medicine and Pharmacy, Vietnam Khanh Cong Nguyen Tran Can Tho Children’s Hospital, VietnamAbstract: Reactive infectious mucocutaneous eruption (RIME) is a mucocutaneous reaction following respiratory infections in children, with diverse skin lesion causes that may lead to misdiagnosis. Although diagnosis is primarily clinical, similar presentations in young children create challenges, particularly for general pediatricians in developing countries, where limited access to skin biopsy adds further difficulty. While Mycoplasma pneumoniae is a common cause, it is rare in children under five, with skin involvement being even less frequent. We report a successfully treated case of RIME due to Mycoplasma pneumoniae, highlighting the importance of accurate diagnosis and appropriate management in such rare cases.en-USEruptionInfectiousRIMEMycoplasma pneumoniaeArticle