Jha, Ujjwal KumarYadav, Ajay Kumar2025-07-312025-07-312024https://hdl.handle.net/20.500.14572/1071Ujjwal Kumar Jha Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal Ajay Kumar Yadav Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalAbstract Staphylococcal Scalded Skin Syndrome is a severe exfoliative skin condition primarily affecting children, caused by the toxins produced by Staphylococcus aureus. A pediatric patient presented with a two-week history of pruritic vesiculobullous eruptions that progressively worsened. Despite initial treatments with various topical and oral medications including steroid and antibiotic ointments, the lesions continued to progress. A wound culture identified heavy growth of Methicillin-Resistant Staphylococcus aureus, prompting a change in the treatment regimen, resulting in significant clinical improvement. The successful outcome with appropriate antibiotic therapy highlights the need for a multidisciplinary approach and emphasizes the value of culture and sensitivity testing in guiding effective treatment strategies.en-USOther