Janardhanan, ArjunRaikar, Poonam SarveshVarghese, ArunPhadke, Abhishek KKumble, AliP, Chaitra2025-10-132025-10-132024https://hdl.handle.net/20.500.14572/2638Arjun Janardhanan Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India. Poonam Sarvesh Raikar Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India. Arun Varghese Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India. Abhishek K Phadke Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India. Ali Kumble Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India. Chaitra P Indiana Hospital and Heart Institute, Mangaluru, Karnataka 575002, India.Abstract: Introduction: Hyperbilirubinemia is one of the most common conditions observed in neonates. Double Volume Exchange Transfusion (DVET) is the most efficient treatment to rapidly reduce the alarmingly high serum bilirubin levels. Methods: This was a retrospective descriptive study of babies who underwent DVET for neonatal hyperbilirubinemia over a five year period. Results: Total 36 babies fulfilling the inclusion criteria were analysed. The mean age of jaundice onset was 41.77 ± 39.79 hours and mean total serum bilirubin (TSB) at admission was 22.54 ± 10.73 mg / dl. Bilirubin induced neurological damage (BIND) was seen in 14 babies at admission. Babies with BIND had significantly higher bilirubin at admission (p - 0.002) and significantly late presentation (p - 0.034) compared to babies with no BIND. Rh hemolytic disease was the most common etiology (55.56%). Most common complication of DVET was thrombocytopenia followed by hypocalcemia. All babies with no BIND had normal neurological examination at discharge. One baby with BIND had abnormal neurological findings at discharge. There was no mortality. Conclusion: DVET is a safe and effective therapy for alarmingly high bilirubin. Timely management with DVET can prevent complications of BIND.en-USAcute bilirubin encephalopathyBINDDouble volume exchange transfusionJaundiceKernicterusNeonatal hyperbilirubinemiaNewbornArticle