Rajouria, Eliz AryalAmatya, AKarn, D2025-08-202025-08-202015https://hdl.handle.net/20.500.14572/1823Eliz Aryal Rajouria Department of Dermatology, Kathmandu University Teaching Hospital A Amatya Department of Dermatology, Kathmandu University Teaching Hospital D Karn Department of Dermatology, Kathmandu University Teaching HospitalAbstract: We present a case of persistent and progressive Bowen's disease (squamous cell carcinoma in situ) in right inner thigh, skin type V in 65 years age female from Ramechap in 2014. Treatment with imiquimod 5% cream was effective when applied once a day for three consecutive days for three month followed by maintenance with cryothrerapy for further three month. Keywords: Benign disease, Liquid nitrogen, Cryotherapy, lmiquimod, Bowen's diseaseen-USArticle