Das, Sunil KumarShahi, ArunPanthi, Ram Chandra2025-12-172025-12-172022https://hdl.handle.net/20.500.14572/3673Sunil Kumar Das Department of General Practice and Emergency Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal https://orcid.org/0000-0002-6568-5149 Arun Shahi Department of Oncology, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal Ram Chandra Panthi Department of Internal Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, NepalAbstract Choriocarcinoma is a malignant trophoblastic tumour usually of placental origin. It is characterized by early metastasis to the brain and lungs. With early detection, it has a better prognosis with treatment. We report a case of 18 years female at 26 weeks of gestation in her third pregnancy who had a history of treatment for metastatic gestational trophoblastic neoplasm with chemotherapy and radiotherapy two years back. Therefore, she was managed as a case of recurrent choriocarcinoma with brain metastasis with chemotherapy (etoposide and cisplatin with etoposide, methotrexate, and dactinomycin) and was responsive. Her symptoms resolved and β-human chorionic gonadotropin dropped to normal value (<2.39 mIU/ml) which has shown that timely diagnosis and management can be vital for the successful treatment of brain metastasis.en-USChemotherapyChoriocarcinomaMetastasisRecurrenceOther