Chalise, RupakPoudel, SarojBist, ManojRegmi, AshimGhimire, AnupKhanal, Kishor2026-02-032026-02-032023https://hdl.handle.net/20.500.14572/4464Rupak Chalise Department of Critical Care Medicine, Nepal Mediciti Hospital Saroj Poudel Department of Critical Care Medicine, Nepal Mediciti Hospital Manoj Bist Department of Critical Care Medicine, Nepal Mediciti Hospital Ashim Regmi Department of Critical Care Medicine, Nepal Mediciti Hospital Anup Ghimire Department of Critical Care Medicine, Nepal Mediciti Hospital Kishor Khanal Department of Critical Care Medicine, Nepal Mediciti HospitalAbstract: Tranexamic acid (TXA) is an antifibrinolytic agent that inhibits the conversion of plasminogen to plasmin, a key step in kallikrein activation and bradykinin formation. Tranexamic acid is used in the prophylactic management of hereditary angioedema; however, evidence for TXA in Non-Steroidal Anti-inflammatory drug-induced angioedema (NSAIDS-AE) is limited. We describe a patient who presented to the ICU department with NSAIDS-AE and was successfully treated with TXA. This case suggests that TXA may be a beneficial treatment modality in the management of NSAIDS-AE and warrants further investigation.en-USAnaphylaxisNon-allergic AnaphylaxisTranexamic acidAngioedemaArticle