Shrestha, SPandey, APathak, R2026-01-092026-01-092024https://hdl.handle.net/20.500.14572/4174Shrestha S,1 Pandey A,2 Pathak R3 1Department of Dermatology Rapti Province Hospital Dang, Tulsipur, Nepa 2Kathmandu University School of Medical Sciences Dhulikhel Hospital, Kathmandu University Hospital Dhulikhel, Kavre, Nepal 3Department of Dermatology Pokhara Academy of Health Sciences Pokhara, NepalABSTRACT Valproic acid is a widely prescribed medication for seizure disorders, mood disorders, and migraines. The adverse effects involving nails following the use of sodium valproate are rare. The nail changes reported so far include onycholysis, onychomadesis, the roughness of the nail, brownish-yellow discoloration, and a transverse yellow band. These changes are independent of the age of the patients, dose, and duration of medication. The nail changes are reversible following the discontinuation of the medication. KEY WORDS Onycholysis, Onychomadesis, Nail discoloration, Valproic aciden-USOnycholysisOnychomadesisNail discolorationValproic acidArticle