Shah, Bipesh KumarYadav, Shankar PrasadNagpal, DheerajPokhrel, NaveenLamichhane, Samiksha2025-08-132025-08-132024https://hdl.handle.net/20.500.14572/1519Bipesh Kumar Shah Department of Pediatrics, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal Shankar Prasad Yadav Department of Pediatrics, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal Dheeraj Nagpal Department of Pediatrics, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal Naveen Pokhrel Department of Pediatrics, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal Samiksha Lamichhane Department of Radiodiagnosis, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, NepalAbstract Hypereosinophilic syndrome with respiratory distress and multiorgan involvement is not so common in children. It is essential to identify this entity based on clinical, laboratory, and imaging features. Corticosteroids should be instituted at the earliest to stabilize the patient and prevent organ damage. Tropical infections are a common secondary cause in children warranting the administration of Diethylcarbamazine. We present a case of an adolescent male in respiratory distress with marked eosinophilia and organs involving the lungs (pulmonary infiltrates with effusion), heart (pericardial effusion), and abdomen (ascites with infiltrates in the liver) which was managed with steroids and anthelmintics. The case highlights the importance of identifying patients with Hypereosinophilic syndrome in pursuing thorough evaluation and commencing therapy.en-USOther