Poudel, SarojKhanal, KishorGhimire, AnupShrestha, PallawiRijal, BishakhaShrestha, AasthaShyaka, SelikaShrestha, AkchhyetaBikram, Yogesh2026-02-022026-02-022024https://hdl.handle.net/20.500.14572/4433Saroj Poudel Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Kishor Khanal Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Anup Ghimire Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Pallawi Shrestha Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Bishakha Rijal Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Aastha Shrestha Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Selika Shyaka Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Akchhyeta Shrestha Department of Critical Care Medicine, Nepal Mediciti, Patan, Nepal Yogesh Bikram Department of Critical Care Medicine, Nepal Mediciti, Patan, NepalAbstract: Intravenous lipid emulsion (ILE) therapy has emerged as a promising treatment for lipophilic drug poisoning, particularly in cases where conventional therapies fail. This case study from Nepal highlights the successful use of ILE therapy in treating a severe calcium channel blocker (CCB) overdose. A 37-year-old female patient with an intentional amlodipine overdose presented with bradycardia, hypotension, and metabolic acidosis. Despite initial treatment with high-dose insulin, calcium gluconate, and inotropic support, her condition remained critical. The initiation of ILE therapy led to rapid hemodynamic stabilization, allowing the discontinuation of vasopressors and normalization of metabolic parameters within 24 hours. The patient recovered without adverse effects and was discharged in stable condition. This case underscores the potential of ILE therapy as a life-saving intervention in severe CCB toxicity and highlights the need for further research to optimize its use in clinical practice.en-USIntravenous Lipid Emulsion Therapylipophilic drug poisoningcalcium channel blockersIntensive Care UnitArticle