Pandey, AsimParajuli, SamriddhiDhungel, AlokDevkota, RahulDongol, Angel2025-12-012025-12-012022https://hdl.handle.net/20.500.14572/3319Asim Pandey Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Samriddhi Parajuli Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Alok Dhungel Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Rahul Devkota Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal Angel Dongol Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, NepalAbstract Toxic epidermal necrolysis is a potentially life-threatening dermatological condition whose pathogenesis and exact treatment are not yet known. Drugs like anticonvulsants, allopurinol and non-steroidal anti-inflammatory drugs like etoricoxib, a selective cyclo-oxygenase-2 inhibitor prescribed for pain management are associated with a high risk of toxic epidermal necrolysis. It is also associated with immunodeficiency and dysregulated immune reactions like systemic lupus erythematosus, an autoimmune disease in which organs and cells undergo damage initially mediated by tissue binding auto-antibodies and immune complexes. Here, a 34 year old lady was presented in emergency with multiple maculopapular rashes over the neck and trunk region after treatment with etoricoxib for osteoarthritis of the left foot.en-USCase reportsEtoricoxibSystemic lupus erythematosusToxic epidermal NecrolysisOther