NepMed is a Nepal MEDLINE(Medical Literature Analysis and Retrieval System Online) by Nepal Health Research Council(NHRC). It includes bibliographic information for articles from academic biomedical journals covering medicine, dentistry, nursing, pharmacy, dentistry veterinary medicine, and allied health sciences.
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Efficacy of Autologous Injectable Platelet Rich Fibrin in Facial Atrophic Acne Scars in Combination with Microneedling: A Randomized Clinical Trial
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2024) Pandey, Katyayani; Agrawal, Sudha; Pandey, Prajwal
Abstract:
Introduction: Several modalities for treating acne scars exist. The combination of microneedling and injectable platelet-rich fibrin (i-PRF) is a synergistic approach.
Objective: The aim was to compare the efficacy of microneedling alone versus microneedling with iPRF in post acne atrophic scars.
Materials and Methods: This study was a hospital-based randomized clinical trial conducted at B P Koirala Institute Health Sciences, Dharan, Nepal. Twenty patients with postacne atrophic scars underwent four sessions of microneedling with-iPRF and microneedling alone, monthly. The Goodman and Baron quantitative score and Goodman and Baron qualitative scores were assessed at zero, four, eight, twelve, and sixteen weeks. The Facial Acne Scar Quality of Life questionnaire (FASQoL) was also evaluated.
Result: The Goodman and Baron quantitative score was reduced from 23 to 14 in microneedling + i-PRF group (p=0.005) and from 16 to 11.50 for microneedling only group (p=0.005).The percentage reduction in the Goodman and Baron quantitative score after the 16th week was 39.13% for group A and 28.12 % for group B. There was a statistically significant difference in the net reduction of the Goodman and Baron quantitative score from the baseline to the 16th week between group A and group B (p=0.004).
Conclusion: Injectable platelet rich fibrin (i-PRF) in combination with microneedling was found effective in reducing lesion count, Goodman and Baron quantitative score, and qualitative grade.
Impact on Quality of Life in Chronic Pruritus in a Tertiary Level Hospital in Kathmandu
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2024) Panta, Arnab; Pokhrel, Dinesh Binod; Parajuli, Sudip
Abstract:
Introduction: Chronic pruritus is a common complaint in various dermatologic as well as non-cutaneous conditions, and it leads to significant impairment in the quality of life of the individuals suffering from it. The 5-D Itch Scale is an internationally validated multidimensional tool for the assessment of the burden of itching, localization patterns, pruritus intensity and evolution, as well as impaired sleep, difficulty in performing daily household activities, and social obligations and responsibilities in school and work.
Objective: To assess the impact on various aspects of quality of life in chronic pruritus in a tertiary level hospital in Kathmandu.
Materials and Methods: This was a hospital-based descriptive cross-sectional study conducted in the Department of Dermatology and Venereology, Tribhuvan University Teaching Hospital, Kathmandu, over a period of one year (October 2020 through September 2021), involving 180 participants. The impact on quality of life was measured with the 5-D Itch Scale.
Results: The mean total 5-D score was 17.06 ± 2.697 (range 8 to 25), showing a severe impact on the quality of life of participants. Pruritus was unbearable in 22.2% and of severe intensity in 47.8% of participants. The impairments in sleep were found to be the most disabling by 40.5% of participants, while the majority of participants (93.9%) had developed some form of disability in leisure or social activities due to chronic pruritus.
Conclusion: Individuals suffering from chronic pruritus face severe deterioration in various aspects of quality of life.
Pattern of Inappropriate use of Topical Corticosteroid and Cutaneous Adverse Effects at a Tertiary Level Hospital in Kathmandu
(Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON), 2024) Bhandari, Sabina; Paudel, Upama
Abstract:
Introduction: Topical corticosteroids are anti-inflammatory, immunosuppressive, and anti-proliferative drugs with profound efficacy. As it provides rapid relief, it is used for a wide spectrum of dermatological conditions. Rampant use of topical corticosteroids due to their easy availability gives rise to difficult-to-treat cutaneous adverse effects.
Objectives: To determine the pattern of inappropriate use of topical corticosteroids and cutaneous adverse effects
Materials and Methods: This was a hospital based cross-sectional prospective study conducted among 84 participants in the Department of Dermatology, Tribhuvan University Teaching Hospital, Kathmandu, from October 2020 to September 2021. Ethical clearance was obtained from the Institutional Review Committee. The participants fulfilling the inclusion criteria were included in the study.
Results: Out of 84 cases, 59.5% were females and 40.5% were males. The mean age of participants was 30.4±9.1years. Dermatophytoses (71.4%) were the most common cause of inappropriate use of topical corticosteroids. The most common adverse effect was tinea incognito (23.8%). The most potent class (60%) of topical corticosteroids were misused. Most of the participants used topical steroids either for the duration of 1 week to 1 month ( 23.8%) or for more than 12 months (23.8%).
Conclusion: Inappropriate topical corticosteroid use is a common problem due to its easy accessibility, resulting in several difficult-to-treat cutaneous adverse effects. So, awareness-raising activities regarding the proper use of corticosteroids have to be conducted.