NepMed is a Nepal MEDLINE(Medical Literature Analysis and Retrieval System Online) by Nepal Health Research Council(NHRC). It includes bibliographic information for articles from academic biomedical journals covering medicine, dentistry, nursing, pharmacy, dentistry veterinary medicine, and allied health sciences.
Recent Submissions
Familial Hypodontia: A Case Series
(Kathmandu University, 2015) Tangade, SP; Ravishankar, TL; Batra, M; Shah, AF
ABSTRACT
The phenomenon of congenitally missing teeth has been described with different
names: hypodontia, oligodontia, anodontia, congenitally missing teeth and dental
agenesis. The present paper reports familial hypodontia, involving two siblings from
a single family. Case I reported the absence of 18, 12, 22 and 31 teeth whereas case
II reported the absence of 31 and 41. On the evaluation of the two reported cases
that were offspring of same parents and absence of any clinical features associated
with any syndrome the final diagnosis of non- syndromic familial hypodontia was
made. Both the cases presented agenesis of the teeth leading to malocclusion and
aesthetic disturbances. Cases were offered a treatment of interdisciplinary dental
approach.
KEY WORDS
Congenital absence, familial, hypodontia, incisor, tooth agenesis.
Relationship of Angiogenesis and Oral Squamous Cell Carcinoma
(Kathmandu University, 2015) Marla, V; Hegde, V; Shrestha, A
ABSTRACT
Angiogenesis is an important aspect of a variety of physiological and pathological
processes; and depends on the alteration of the balance between pro-angiogenic
and anti-angiogenic factors. The role of angiogenesis in the progression and
metastasis of neoplasm is a well established phenomenon. With regards to oral
squamous cell carcinoma, it is a field of ongoing research and requires validation for
it being used as a mode of anti-cancer therapy. This review focuses on the concept
of angiogenesis, the factors associated with it, the relationship of angiogenesis with
oral epithelial dysplasia and oral squamous cell carcinoma; the methods of studying
angiogenesis and anti angiogenic therapy.
KEY WORDS
Angiogenesis, neoplasm, oral squamous cell carcinoma.
Six Minute Walk Distance and Reference Equations in Normal Healthy Subjects of Nepal
(Kathmandu University, 2015) Shrestha, SK; Srivastava, B
ABSTRACT
Background
The self-paced six minute walk test is a simple assessment for sub-maximal functional
capacity. It correlates well with sophisticated tests and gives good prediction for
morbidity, mortality, quality of life and pulmonary functions.
Objective
To evaluate six minute walk distance in healthy adults to identify reference values
and formulate reference equations.
Method
We conducted six minute walk test on 250 random volunteers at and above 18 years
of age as per standard protocol. Age, gender, height and weight were measured. Pre-
test and post-test vital parameters were recorded including pulse oximetry. The six
minute walking distance was identified in all subjects. Multiple regression analysis
was done to formulate regression equations to predict six minute walking distance.
This also correlated age, gender, height, weight, body mass index with six minute
walking distance.
Result
The mean six minute walking distance was 489±86 meters with males walking 509±82
meters and females 445±78 meters. Age, gender, weight and body mass index had
significant contribution for prediction of six minute walking distance. Gender was
the single most important predictor. Height had the least significance. Depending
on coefficients of these variables we formulated three regression equations and
tested them for accurate prediction. The two best equations were identified as:
Predicted SMWD = 395–1.5xAge+2.47xWT–35.89xGender and Predicted SMWD =
440–1.82xAge–53.07xGender+5.12xBMI.
Conclusion
Gender, age and height are the most important predictors of six minute walking
distance. Reference values and equations for both genders, different age groups with
varying weights were derived for local population.
KEY WORDS
Predicted equation, reference values, six minute walk test.