Browsing by Author "Adak, M"
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Publication Age related study of serum lipid peroxidation and antioxidant status(Institute of Medicine, 2007) Adak, M; Nazri, SAbstract Background: Ageing is a common phenomenan throughout the globe which is characterized by an impaired ability to maintain homeostasis under the condition of physiological stress. Some parameters in serum like malondialdehyde(MDA) , â-carotene, vita-E etc. are useful marker for chronological ageing. To validate the usefulness of the above parameters as an indicators for chronological ageing in Indian subjects. Materials and Methods: Blood samples were randomly collected from healthy 50 male and 50 female volunteers ranging in age 20-70 years who were coming for routine checkup to OPD in IGIMS, Patna. Fasting blood sample (10 ml) was collected from each individual for estimation of fasting blood sugar(FBS), malondialdehyde(MDA), Vita-E and â-carotene. Results: Serum MDA levels of these subjects were increased and lowering trend was observed in women. However, Vita-E levels were marginally decreased with age but no significant change in FBS levels were observed. An interesting observation was seen in â–carotene levels decreases markedly after attending the age of 40 years and the lowering tendency remain 70 years of age. Conclusion: A significant increased levels of MDA and decreased levels of â-carotene were useful marker for the study of chronological ageing in Indian subjects.Publication Prevalence of anaemia among young girls and pregnant women of Birgunj, Nepal(Institute of Medicine, 2006) Adak, M; Nazri, SAbstract Background: The prevalence of anaemia is a major health problem worldwide and is high particularly among young girls and pregnant women. A perusal of the literature on anaemia prevalence in semi urban areas of Nepal is very alarming and its magnitude increases day to day. Methods: All the patients with illness attending at OPD of NMC Hospital were included in the study. Social demographic profile, morbidity data were recorded on a structured questionnaire. Anthropometric measurements and BMI were recorded on the basis of National Health and Nutritional Examination Survey. Hb was estimated by Sahli’s method and pregnancies were verified with urine specimen using on HCG testing kit. Results: In the sample of 552 patients, 54-64.2 % were anaemic .Out of which, 26.9 % of pregnant women were moderately anaemic and 3.1 % subject were severe anaemic. Conclusions: Higher prevalence of anaemia among young in Birgunj was alarming looking due to either lesser consumption of green leafy vegetable or habit of post meal tea/coffee drinking or smaller intake of citrus fruits. These findings suggest that guideline for screening for anaemia may need to further study in relation to the dietary level of iron, iron and ferritin level in blood. Keywords: Anaemia, young grils, pregnant women, semi urban areaPublication Risk factors assessment for Type-II Diabetes Mellitus(Institute of Medicine, 2008) Adak, M; Nazri, SAbstract Introduction: Diabetes mellitus is a group of metabolic abnormality often deliberating with sever complications of retinopathy, nephropathy and microangiopathy1 , which is one of the most common endocrine disorders in all populations and all age groups. Materials and Methods: This is a retrospective study. A total of 1118 adult subjects were enrolled in the OPD in NMCTH. The case records of the patients of both genders aged range from 20-70 years. A definitive diagnosis was made based on clinical features, fasting blood sugar, post- Prandial blood sugar and lipid profiles estimation. Results: Out of total patients, 142 were male and 71 were female Type –II diabetes patients. Male diabetes was maximum in 41-50 years age groups. Associated risk factors and co-morbid conditions were analyzed. Factors like physical activity, socio-economical status, family history, obesity have shown statistically significant association with diabetes mellitus. About 42 % have systolic BP> 140 mm of Hg and 47 % have diastolic BP> 80 mm of Hg. Conclusion: This study showed a trend of diabetes with age in both sexes, reaching the highest in the age 41-50 years. Based on our study, we may concluded that these factors need to be addressed in prevention and control strategies in this area. Keywords: Type-II diabetes mellitus, blood sugar level, hypertension, dyslipidemiaPublication Studies on anti-hypercholesterolemic activity of Indanyl tetrazoles(Institute of Medicine, 2010) Adak, MAbstract Introduction: Clinically useful non-steroidal antihyperlipidemic drugs are now in the market for the treatment of patients suffering from hypercholesterolemia. Indan acids, which belong to non-steroidalaryl alkanoic acids class acids have been reported to possess varying degrees of cholesterol lowering activity. Keeping the above points in view exploration for better anti-hypercholesterolemic activity of indanyl tetrazole derivatives was undertaken. Methods: Five-week-old male albino Charles Foster rats (120± 10 g) for normocholesterolemic and seven-week-old rats (130±10g) for hypercholesterolemic studies were used. On the 0-day and 14thday, tail vein blood was drawn from the overnight fasted animals respectively. Biochemical measurements were carried out using biochemical kits (Span, India) and an automated biochemical analyzer (Vitros-250, Johnson and Johnson Co. USA). Results: The compound - V and VI exhibited almost same significant level of cholesterol lowering(p<0.01) activity. On closer look its reveal that the compound-VI exhibit triglyceride lowering (p<0.01) activity among the groups around 14 days of treatment on normocholesterolemic rats. Test compound-V (p<0.05) and compound-VI (p<0.001) have significant anti-hyper-cholesterolemic activity while clofibrate has no such activity on hypercholesterolemic rats. Conclusions: Indanyl tetrazole derivatives, 5-(62 -methoxyindan-12 -yl) methyltetrazole (V) and 5-(52 , 62 -dimethoxyindan-12 -yl) methyltetrazole (VI) were more promising than their analogs in respect to their anti-hypercholesterolemic activity.