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NepMed is a Nepal MEDLINE(Medical Literature Analysis and Retrieval System Online) by Nepal Health Research Council(NHRC). It includes bibliographic information for articles from academic biomedical journals covering medicine, dentistry, nursing, pharmacy, dentistry veterinary medicine, and allied health sciences.

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Article

2D shear wave elastography of normal thyroid gland in nepalese population

(Nepal Medical College Pvt. Ltd., 2024) Shrestha, Amit; Shrestha, Subodh; Adhikari, Parash; Khanal, Roja; Poudel, Prabhat; Pradhan, Sunil; Tuladhar, Abhushan Siddhi; Acharya, Riwaz

Abstract: Ultrasonography (USG) is modality of choice for normal, diffuse or nodular thyroid diseases. Two dimensional shear wave elastography (2D-SWE) is the latest innovation in USG techniques that allows real-time quantitative assessment of tissue stiffness using acoustic radiation force impulse (ARFI) induced by ultrafast focused US beam sequence (up to 20,000Hz) to record the propagation of the shear waves in real time and displays a map that represents the local elasticity values of tissues in real-time and in a quantitative manner without any compression of the organ. At times, there are difficulties in differentiating normal thyroid gland from diffuse thyroid disease based solely on gray scale USG for which 2D-SWE can be an adjunct. This study aims to establish 2D-SWE parameters for normal thyroid gland in Nepalese population. A cross sectional descriptive study was carried out with 2D SWE on all euthyroid patients with normal thyroid gland on B-mode USG at Department of Radiology, Nepal Medical College Teaching Hospital between December 2021 and November 2022. Tissue stiffness of normal thyroid gland was recorded and tabulated in terms of SMV units (m/s) according age and gender. Out of 100 subjects ( 52 females and 48 males) the youngest was 16 year female and oldest was 68 year female with mean age of 37.07 year (S.D = 11.58). Minimum mean velocity of 1.78 m/s was seen in 36 year old male and maximum of 3.40 m/s in 26 year old female. Mean of mean velocity was 2.36 m/s with (S.D= 0.34). Linear positive correlation was seen between shear wave velocities and age with no statistically significant difference between genders. This study had the most number of normal subjects (100) with almost equal gender distribution (52 females and 48 males) compared to previous studies in known literature. This study also analyzed correlation of shear wave velocity with age unlike other studies. Statistically significant correlation was seen between age and velocities in males only and also in mean velocities between age group 21-40 and 41-60 years (p-value= 0.037).

Article

Measurement of anterior maxillary alveolar ridge dimension and assessment of sagittal root position by cone beam computerized tomography (CBCT)

(Nepal Medical College Pvt. Ltd., 2024) Rajkanikar, Junima; Vaidya, Samriddhi; Koju, Sushmit

Abstract: Maxillary anterior region is the implant site that may require the most rigorous pre-operative assessment as it will have a direct influence on aesthetic outcome and stability of the dental implant. In the present study, CBCT (cone beam computerized tomography) images were used to evaluate alveolar ridge dimension in the maxillary anterior region. This observational radiographic study was done at Nepal Medical College Teaching Hospital. The width of the alveolar bone was measured from the labial cortex to the palatal cortex of the maxillary anterior teeth in mm at the alveolar crest (L1), mid-root (L2), and apical root region (L3) for each tooth. Alveolar height was also measured from the alveolar crest to the floor of the nasal fossa. The Sagittal Root Position (SRP) of the maxillary anterior teeth was also assessed. Results showed that the maximum width of the alveolar bone was seen at L3 of canine and lateral incisor showed least width of alveolar bone width at L1. Maximum alveolar bone height was seen in canines. Males were seen to have increased width of the alveolar bone as compared to the females in all anterior teeth. The most frequent sagittal root position was class I which was seen in 270 (51.4%) of the total teeth examined, which was followed by class IV observed in 210 (40%) of the teeth examined. It could be concluded that for maxillary anterior region, additional regeneration therapy maybe required since class I is the most frequent SRP observed.

Article

Functional outcome of acromioclavicular joint dislocation type III injuries treated with hook plate

(Nepal Medical College Pvt. Ltd., 2024) Adhikari, Vijayendra; Sitaula, Prasamsha; Singh, Sumi; Shrestha, Praphulla; Chalise, Pralhad Kumar; Mishra, Anil Kumar; Singh, Ramesh Prasad

Abstract: The acromioclavicular joint (AC) dislocation is a complex injury due to the disruption of ligaments and joints, leading to instability and pain. Rockwood type III injuries remain controversial, so clinical evaluation should be taken into consideration before deciding the treatment modalities. The study aimed to evaluate the functional outcome of AC joint dislocation type III injuries treated with a hook plate. A total of 30 patients with AC Joint Dislocation Type III injuries were treated with open reduction and fixation with hook plate during a period of 18 months. The functional outcome was evaluated using constant murley score, the mean score of which was 82 (58-96). There were 7 (23.33%) cases of plate impingement and the symptoms was improved after plate removal. The hook plate is a good fixation device for the treatment of AC joint dislocation -Rockwood type III injuries with minimal complications, as it is a simple procedure, with good functional outcome, without ligamentous procedure and the only drawback is second surgery for implant removal.

Article

Evaluation of leiomyoma: a clinicopathological study in a Tertiary Care Center in Kathmandu

(Nepal Medical College Pvt. Ltd., 2024) Pathak, Rakesh; Khadka, Anu; Maharjan, Bipin; Shrestha, Monika

Abstract: Uterine leiomyoma is one of the common gynecological benign tumors. It is usually observed in female of reproductive age group and often presented with symptoms like abdominal pain, dysmenorrhea and fertility disorders. Hysterectomy and myomectomy are the procedure for management of uterine leiomyoma. The prime objective of our study was to evaluate the demographic distribution and clinicopathological changes in hysterectomy and myomectomy specimens with leiomyomas. A descriptive hospital based cross-sectional study was conducted in the Department of Pathology, Nepal Medical College Teaching Hospital (NMCTH), Nepal from May 2023 to October 2023. A total of 57 uterine leiomyoma samples received in the department of Pathology for histopathological examination were included in the study. Ethical approval for the study was obtained from Institutional Review Committee of NMCTH and informed consent was taken from each patient. The tissue biopsies were routinely processed and stained with Hematoxylin and Eosin (H and E). The observed findings were managed in MS Excel sheet and later analyzed using SPSS 17. The most common age group diagnosed with uterine leiomyoma was 41 to 50 years (64.9%). The leiomyomas were highly prevalent in women from Janajati community (47.4%). Pelvic pain, menorrhagia and bleeding disorders were the most frequent clinical manifestations. Intramural was the commonest site (77.2%) and the hyalinization was the most usual secondary changes (19.2%) found. The correlation between age distribution and site of leiomyoma, age distribution and secondary changes and site of leiomyoma and secondary changes were statistically not significant. However, detailed histopathological examination gives many information related to leiomyoma and it is necessary for the effective management.

Article

Knowledge of periconceptional folic-acid among women of childbearing age visiting Tertiary Care Hospital in Nepal

(Nepal Medical College Pvt. Ltd., 2024) Adhikari, Kushal; Basnet, Bijay; Acharya, Suyukti; Shrestha, Astha

Abstract: The value of periconceptional folic acid supplementation in reducing the incidence of neural tube abnormalities in newborns is widely known. Yet, Nepalese women of childbearing age are mainly ignorant of it. The current study examined different sociodemographic and health factors related to women’s level of knowledge about folic acid among women visiting Obstetrics and Gynaecology outpatients at a Tertiary Care Center in Nepal. It also evaluated the awareness and relevance of knowledge regarding folic acid and its periconceptional supplementation. 400 women aged 18 and 45 who sought Obstetrics and Gynecology Outpatient Services at the Tertiary Care Facility participated in this cross-sectional study. Sociodemographic information was gathered with the help of a self-report questionnaire and processed in IBM-SPSS software at a significance threshold of 0.05. Results of the studies showed that while 47.3% had heard of it, only 34.25% had adequate knowledge of periconceptional folic acid supplementation. Also, besides age (p=.493), knowledge of folic acid was significantly associated with factors including education(p=.026), ethnicity (p=<.001), income (p=.011), employment (p=.001), marital status (p=.007), past pregnancies (p=.031) and ANC visits (p=<.001). The study demonstrates the need for more public awareness to boost folic acid knowledge, adherence, and intake and ultimately lower the prevalence of related birth abnormalities. To quantify the hidden issue, further studies on the prevalence of NTDs in Nepalese society and the contribution of folic acid to their reduction are required.

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