Browsing by Author "Agrawal, Shweta"
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Publication Hashimoto’s Thyroiditis among Patients with Thyroid Disorders Visiting a Tertiary Care Centre(Nepal Medical Association, 2023) Parajuli, Suraj; Bhatt, Navin; Regmi, Anil; Chapagain, Subodh; Panday, Pradumna; Singh, Arjan; Nepal, Shristi; Karki, Pragya; Agrawal, Shweta; Bhattarai, JyotiAbstract Introduction: Hashimoto’s thyroiditis is a chronic autoimmune lymphocytic thyroiditis characterised by thyroid autoantibodies. Early detection and treatment of this condition help in reducing the morbidity and mortality associated with it. The aim of the study was to find out the prevalence of Hashimoto’s thyroiditis among patients with thyroid disorders visiting a tertiary care centre. Methods: A descriptive cross-sectional study was conducted among patients visiting the outpatient department of a tertiary care centre. Data from 14 April 2017 to 13 April 2019 was collected between 30 June 2022 to 15 September 2022 from medical records. Ethical approval was obtained from the Nepal Health Research Council. Hashimoto’s thyroiditis was diagnosed based on clinical presentation and positive antibodies to thyroid antigens. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval. Results: Among 813 patients with thyroid disorders, 393 (48.33%) (44.89-51.77, 95% Confidence Interval) had Hashimoto’s thyroiditis. The manifestation of the spectrum of Hashimoto’s thyroiditis were euthyroid in 215 (54.70%), subclinical hypothyroidism in 102 (25.95%), subclinical hyperthyroidism in 23 (5.85%), overt hyperthyroidism in 9 (2.30%) and overt hypothyroidism in 4 (1.02%). Conclusions: The prevalence of Hashimoto’s thyroiditis among patients with thyroid disorders was higher than in other studies done in similar settings.Publication Type 2 Diabetes Mellitus in Patients with Periodontitis at a Tertiary Care Hospital: A Cross-Sectional Study(Nepal APF Hospital, 2026) Shrestha, Sweta; Agrawal, Shweta; Thakur, Amresh; Bhattarai, RosinaAbstract: Introduction: Periodontitis is a chronic inflammatory disease affecting the tissues surrounding the teeth. Bacteria or bacterial products may enter the general circulation through the ulcerated periodontal pocket, and cytokines produced locally will also have systemic effects, altering the body's internal environment and causing insulin resistance. The aim of this study was to determine glycemic parameters among patients diagnosed with chronic periodontitis. Methods: This descriptive, cross-sectional study was conducted among 350 patients diagnosed with chronic periodontitis at a tertiary-level hospital from February 2025 to August 2025. Ethical approval was obtained from the Institutional Review Committee (Ref 030/2024). The patients were recruited by convenience sampling, written informed consent was obtained and they were sent for glycemic parameters. Data were entered in Statistical Package for the Social Sciences version 21 and Microsoft Excel 2019. Chi-square test was utilized to compare categorical data. Results: Among 350 participants with periodontitis, the majority, 219 (62.60%) had normal glycemic levels. However, a substantial proportion showed dysglycemia in which 87 (24.90%) were classified as having pre-diabetes and 44 (12.60%) had diabetes mellitus. The chi-square test suggested that, with progression of periodontitis, poor glycemic control was observed, and periodontitis staging showed significant associations with glycemic status (p < 0.001). Conclusions: Glycemic parameters were higher in patients with periodontitis. The study showed a significant correlation between the severity of periodontitis and poor glycemic control.